• Handheld endomicroscope using a fiber-optic harmonograph enables real-time and in vivo confocal imaging of living cell morphology and capillary perfusion

  AbstractConfocal laser endomicroscopy provides high potential for noninvasive and in vivo optical biopsy at the cellular level. Here, we report a fully packaged handheld confocal endomicroscopic syste

  2020-09-21

• Antibody engineers seek optimal drug targeting TIGIT checkpoint

  Four antibodies are already in trials to test efficacy against the emerging checkpoint molecule TIGIT, but debate swirls around the importance of Fc binding for drug action.The race to develop a first

  2020-09-19

• ‘CRISPR babies’ are still too risky, says influential panel

  Human embryos could be edited to fix genes that cause disease. Credit: Dr Yorgos Nikas/SPLEditing genes in human embryos could one day prevent some serious genetic disorders from being passed dow

  2020-09-03

• Trending Clinical Topic: Multiple Sclerosis

  Each week, we identify one top search term, speculate about what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, share

  2020-08-29

• The COVID-19 XPRIZE and the need for scalable, fast, and widespread testing

  To the Editor — The US Food and Drug Administration (FDA) Emergency Use Authorization (EUA) and Instructions for Use (IFU) documents outlining the current approved virology tests for SARS-CoV-2 a

  2020-08-20

• Plasma-based early screening and monitoring of EGFR mutations in NSCLC patients by a 3-color digital PCR assay

  AbstractBackgroundNoninvasive plasma-based detection of EGFR mutations using digital PCR promises a fast, sensitive and reliable approach to predicting the efficiency of EGFR-TKI. However, t

  2020-08-20

• 抗癌潜力新靶点——PRL2

  许多类型的人类肿瘤都会表现出蛋白激酶和磷酸酶平衡的变化。抑制激酶活性的药物在临床上已经是一种成功的抗癌疗法，但是磷酸酶这类靶点在很大程度上仍然没有被充分利用，究其原因，主要是由于目前对磷酸酶引发疾病的机制认识还不足。8月11日，PNAS发表了普渡大学Zhong-Yin Zhang教授团队的最新进展，他们发现了一种在胰腺癌、肝癌、肾癌、肺癌、乳腺癌、前列腺癌、脑癌和其它多种类型癌症中起着关键作用的新

  2020-08-19

• Cell突破成果：PD-1抗体联合TREM2抑制剂，小鼠肿瘤完全消退！

  为了逃避免疫系统的监视，癌细胞会减弱自身的免疫原性特征，并在其内部和周围诱导出抑制性免疫微环境来抑制T细胞的应答。虽然免疫检查点抑制剂可唤醒沉默的T细胞来攻击肿瘤，但如果肿瘤微环境的免疫抑制作用仍然存在，那么只使用检查点抑制剂可能并不足以消除肿瘤。8月11日，在Cell发表的一项新研究中，华盛顿大学医学院的研究人员通过阻断TREM2蛋白增强了PD-1抗体的作用，从而完全消除了小鼠的肿瘤。这项研究发

  2020-08-12