• Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality

  AbstractWearable devices can capture unexplored movement patterns such as brief bursts of vigorous intermittent lifestyle physical activity (VILPA) that is embedded into everyday life, rather than bei

  2022-12-29

• Cancer immunotherapy: the quest for better biomarkers

  Checkpoint-blockade immunotherapy has transformed cancer therapeutics but still benefits only a subset of patients. The development of more-robust biomarkers of response could change that.Immune-check

  2022-12-24

• Eight rules to combat medical misinformation

  Authors of biomedical research should provide clear and accurate information to society, whilst working to combat misinformation and disinformation.Vaccination, hydroxychloroquine, masks and long COVI

  2022-12-14

• Atezolizumab plus anthracycline-based chemotherapy in metastatic triple-negative breast cancer: the randomized, double-blind phase 2b ALICE trial

  AbstractImmune checkpoint inhibitors have shown efficacy against metastatic triple-negative breast cancer (mTNBC) but only for PD-L1positive disease. The randomized, placebo-controlled ALICE tria

  2022-12-09

• Efficacy of supermarket and web-based interventions for improving dietary quality: a randomized, controlled trial

  AbstractDietary interventions may best be delivered at supermarkets, which offer convenience, accessibility, full food inventories and, increasingly, in-store registered dietitians, online shopping an

  2022-12-02

• Prospective evaluation of smartwatch-enabled detection of left ventricular dysfunction

  AbstractAlthough artificial intelligence (AI) algorithms have been shown to be capable of identifying cardiac dysfunction, defined as ejection fraction (EF) ≤ 40%, from 12-lead electrocardiograms (ECG

  2022-11-15

• A Food is Medicine approach to achieve nutrition security and improve health

  Suboptimal nutrition is a leading cause of illness, healthcare spending and lost productivity, predominantly from diet-related chronic diseases but also from undernutrition1,2. These burdens are not e

  2022-10-07

• Africa must participate in finding a gene therapy cure for sickle-cell disease

  Sickle-cell disease (SCD) is the most common serious inherited disease, with 300,000 affected individuals born yearly worldwide, with three-quarters of them in Africa.

  2022-10-06