• Machine learning model to predict mental health crises from electronic health records

  AbstractThe timely identification of patients who are at risk of a mental health crisis can lead to improved outcomes and to the mitigation of burdens and costs. However, the high prevalence of mental

  2022-05-16

• Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

  AbstractKMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic le

  2022-03-14

• The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial

  AbstractThe sodium–glucose cotransporter 2 inhibitor empagliflozin reduces the risk of cardiovascular death or heart failure hospitalization in patients with chronic heart failure, but whether empagli

  2022-02-24

• Microbiome and metabolome features of the cardiometabolic disease spectrum

  AbstractPrevious microbiome and metabolome analyses exploring non-communicable diseases have paid scant attention to major confounders of study outcomes, such as common, pre-morbid and co-morbid condi

  2022-02-18

• Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial

  AbstractAutism spectrum disorder (ASD) is defined by hallmark behaviors involving reduced communication and social interaction as well as repetitive activities and restricted interests. ASD represents

  2022-02-15

• Optimizing risk-based breast cancer screening policies with reinforcement learning

  AbstractScreening programs must balance the benefit of early detection with the cost of overscreening. Here, we introduce a novel reinforcement learning-based framework for personalized screening, Tem

  2022-01-13

• Extent of Lymphadenectomy Predicts Survival in Esophageal Cancer

  NEW YORK (Reuters Health) - Extended lymphadenectomy independently predicts improved survival following induction neoadjuvant chemoradiation (CRT) in patients with esophageal cancer, a new study has f

  2021-09-29

• Trove of CRISPR-like gene-cutting enzymes found in microbes

  The Cas9 enzyme — known as CRISPR’s molecular scissors — is used to find and cut specific DNA sequences.Credit: NatureBy exploring the evolutionary origins of an enzyme used in the CRISPR genome-editi

  2021-09-27