• Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential

  AbstractCancer stemness, referring to the stem-cell-like phenotype of cancer cells, has been recognised to play important roles in different aspects of hepatocarcinogenesis. A number of well-establish

  2020-03-26 2533

• HHLA2 is expressed in pancreatic and ampullary cancers and increased expression is associated with better post-surgical prognosis

  AbstractBackgroundHHLA2 is a recently discovered member of the B7-family of immune checkpoint molecules with limited expression in normal tissues but overexpression in several types of cancer. The aim

  2020-02-06 2213

• Clinical Genome Data Model (cGDM) provides Interactive Clinical Decision Support for Precision Medicine

  AbstractIn light of recent developments in genomic technology and the rapid accumulation of genomic information, a major transition toward precision medicine is anticipated. However, the clinical appl

  2019-12-30 587

• Tumours use a metabolic twist to make lipids

  To survive and divide, cancer cells need a constant supply of lipid molecules called monounsaturated fatty acids. Tumours can achieve this by an unsuspected route that harnesses a metabolic pathway also used in hair follicles.

  2019-02-12 1994

• Study of mutation order may change understanding of how tumors develop

  Cancers most commonly arise because of a series of two to five mutations in different genes that combine to cause a tumor. Evidence from a growing number of experiments focused on truncal mutations -- the first mutations in a given sequence -- suggests a new direction in understanding the origins of cancer.

  2019-01-16 743

• Study provides new insight into generation of new neurons in adulthood

  Researchers at Sahlgrenska Academy at the University of Gothenburg, Sweden, in collaboration with research groups in Finland, Canada, and Slovenia, have discovered a novel and unexpected function of n

  2019-01-04 2191

• First baby born via uterus transplant from a deceased donor

  Currently, uterus donation is only available for women with family members who are willing to donate. With live donors in short supply, the new technique might help to increase availability and give more women the option of pregnancy.

  2018-12-10 490

• Prostate cancer: Scientists reveal new way to target stubborn cells

  A new compound that targets hard-to-treat prostate cancer cells may pave the way for a new, more successful treatment in the future, a new study reports.The study, which is now published in 

  2018-11-09 942