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  First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial

  AbstractFirst-line systemic therapeutic options for advanced esophageal squamous cell carcinoma (ESCC) are limited. In this multicenter, double-blind phase 3 trial, a total of 551 patients with previo

  2023-02-03

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  Cancer immunotherapy: the quest for better biomarkers

  Checkpoint-blockade immunotherapy has transformed cancer therapeutics but still benefits only a subset of patients. The development of more-robust biomarkers of response could change that.Immune-check

  2022-12-24

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  Efficacy of supermarket and web-based interventions for improving dietary quality: a randomized, controlled trial

  AbstractDietary interventions may best be delivered at supermarkets, which offer convenience, accessibility, full food inventories and, increasingly, in-store registered dietitians, online shopping an

  2022-12-02

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  Long-term cardiac pathology in individuals with mild initial COVID-19 illness

  AbstractCardiac symptoms are increasingly recognized as late complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in previously well individuals with mild initial il

  2022-09-06

• Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial

  AbstractNicotine replacement therapy, in the form of nicotine patches, is commonly offered to pregnant women who smoke to help them to stop smoking, but this approach has limited efficacy in this popu

  2022-05-24

• Discovery of a small protein-encoding cis-regulatory overlapping gene of the tumor suppressor gene Scribble in humans

  AbstractIntensive gene annotation has revealed many functional and regulatory elements in the human genome. Although eukaryotic protein-coding genes are generally transcribed into monocistronic mRNAs,

  2021-09-25

• Nanopore electro-osmotic trap for the label-free study of single proteins and their conformations

  AbstractMany strategies have been pursued to trap and monitor single proteins over time to detect the molecular mechanisms of these essential nanomachines. Single-protein sensing with nanopores is par

  2021-08-04

• Ultrastructural analysis in yeast reveals a meiosis-specific actin-containing nuclear bundle

  AbstractActin polymerises to form filaments/cables for motility, transport, and the structural framework in a cell. Recent studies show that actin polymers are present not only in the cytoplasm but al

  2021-08-03