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  Parental inflammatory bowel disease and autism in children

  AbstractEvidence linking parental inflammatory bowel disease (IBD) with autism in children is inconclusive. We conducted four complementary studies to investigate associations between parental IBD and

  2023-02-27

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  Seeking therapeutic synergy in BRAF mutant colorectal cancer

  In a phase I trial, the combination of dabrafenib, trametinib and spartalizumab uncovers the crosstalk between the MAPK pathway and the immune system, which offers a promising new strategy to improve

  2023-01-31

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  Brain lesions disrupting addiction map to a common human brain circuit

  AbstractDrug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to addiction remission. These cases may be used to identify

  2022-09-13

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  Four areas of health innovation boosted by the pandemic

  Leading researchers explain how the COVID-19 pandemic has spurred research on wearables, genomic surveillance, behavioral interventions and drug discovery.The creation of vaccines against the novel co

  2022-06-13

• Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

  AbstractKMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic le

  2022-03-14

• Trove of CRISPR-like gene-cutting enzymes found in microbes

  The Cas9 enzyme — known as CRISPR’s molecular scissors — is used to find and cut specific DNA sequences.Credit: NatureBy exploring the evolutionary origins of an enzyme used in the CRISPR genome-editi

  2021-09-27

• Low Glycemic Diet Improves A1c, Other Risk Factors in Diabetes

  A diet rich in vegetables and low in carbs — a so-called low glycemic index (GI) diet ― is associated with clinically significant benefits beyond those provided by existing medications for people with

  2021-08-04

• Diabetes Duration Linked to Increasing Heart Failure Risk

  The longer a person has diabetes, the greater their risk for also developing heart failure, according to an analysis of nearly 10,000 U.S. adults followed for a median of close to 23 years.In a m

  2021-07-26