• PCOS Tied to Risk for Cardiovascular Disease After Menopause

  Women with polycystic ovarian syndrome (PCOS) before menopause appear to have a greater risk of stroke, heart attack, and other cardiovascular events after menopause, according to findings presented S

  2020-10-19

• Vitamin D deficiency during early development can influence metabolic health

  Using a zebrafish model, researchers from North Carolina State University have found that vitamin D deficiency during early development can disrupt the metabolic balance between growth and fat accumul

  2020-09-29

• Cell突破成果：PD-1抗体联合TREM2抑制剂，小鼠肿瘤完全消退！

  为了逃避免疫系统的监视，癌细胞会减弱自身的免疫原性特征，并在其内部和周围诱导出抑制性免疫微环境来抑制T细胞的应答。虽然免疫检查点抑制剂可唤醒沉默的T细胞来攻击肿瘤，但如果肿瘤微环境的免疫抑制作用仍然存在，那么只使用检查点抑制剂可能并不足以消除肿瘤。8月11日，在Cell发表的一项新研究中，华盛顿大学医学院的研究人员通过阻断TREM2蛋白增强了PD-1抗体的作用，从而完全消除了小鼠的肿瘤。这项研究发

  2020-08-12

• 癌症免疫治疗新靶点——NRP1

  虽然抗PD-1/L1等免疫检查点阻断（immune checkpoint blockade，ICB）疗法已经彻底改变了癌症治疗，但只有一小部分（10%–30%）癌症患者表现出持久的临床反应。因此，人们对识别先前存在和获得性免疫耐药机制以及开发新的预防复发的治疗方法非常感兴趣。7月13日，UPMC Hillman癌症中心和匹兹堡大学医学院的研究人员在Nature Immunology上发表文章揭示了

  2020-07-13

• Blood Test Could Spot Breast Cancer Early

  By Dennis ThompsonHealthDay ReporterWEDNESDAY, June 10, 2020 (HealthDay News) -- A cutting-edge "lab-on-a-chip" has shown promise in detecting early breast cancers and tumors that have devel

  2020-06-10

• Middle-Age Obesity Linked to Higher Odds for Dementia

  By Steven ReinbergHealthDay ReporterTHURSDAY, June 25, 2020 (HealthDay News) -- If you've been looking for a good reason to slim down, consider this: Being obese at midlife appears to increase you

  2020-06-02

• Bypass of premature stop codons and generation of functional BRCA2 by exon skipping

  AbstractA pathogenic mutation in BRCA2 significantly increases the risk of breast and ovarian cancers making it imperative to examine the functional consequences of variants of uncertain cli

  2020-05-27

• Study reveals the effect of ancestry on molecular makeup of cancer

  Questions about the genealogical imprint of tumors have hovered over cancer research since the completion of the Human Genome Project in 2003. Is liver cancer different at a basic, molecular level in

  2020-05-17