• Enhancing the tropism of bacteria via genetically programmed biosensors

  AbstractEngineered bacteria for therapeutic applications would benefit from control mechanisms that confine the growth of the bacteria within specific tissues or regions in the body. Here we show that

  2021-07-02

• Droplet-based microfluidic platform for high-throughput screening of Streptomyces

  AbstractStreptomyces are one of the most important industrial microorganisms for the production of proteins and small-molecule drugs. Previously reported flow cytometry-based screening methods ca

  2021-06-23

• Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging

  AbstractHuman induced pluripotent stem cell-derived (iPSC) neural cultures offer clinically relevant models of human diseases, including Amyotrophic Lateral Sclerosis, Alzheimer’s, and Autism Spectrum

  2021-05-03

• Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor

  Simple and fast methods for the detection of target genes with single-nucleotide specificity could open up genetic research and diagnostics beyond laboratory settings. We recently reported a biosensor

  2021-04-20

• Percutaneous radiofrequency ablation for atrial fibrillation

  The National Institute for Health and Clinical Excellence (NICE) has issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on percutaneous radiofrequency catheter ablation f

  2021-04-02

• A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection

  There is a global unmet need for rapid and cost-effective prognostic and diagnostic tools that can be used at the bedside or in the doctor’s office to reduce the impact of serious disease. Many cancer

  2021-03-20

• Cardiomyocyte electrical-mechanical synchronized model for high-content, dose-quantitative and time-dependent drug assessment

  Cardiovascular diseases have emerged as a significant threat to human health. However, drug development is a time-consuming and costly process, and few drugs pass the preclinical assessment of safety

  2021-03-01

• Engineering multifunctional bactericidal nanofibers for abdominal hernia repair

  The engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge.

  2021-02-20