• A microfluidic platform for cultivating ovarian cancer spheroids and testing their responses to chemotherapies

  AbstractThere is increasing interest in utilizing in vitro cultures as patient avatars to develop personalized treatment for cancer. Typical cultures utilize Matrigel-coated plates and media to promot

  2020-10-19

• Electrochemical measurement of serotonin by Au-CNT electrodes fabricated on microporous cell culture membranes

  AbstractGut–brain axis (GBA) communication relies on serotonin (5-HT) signaling between the gut epithelium and the peripheral nervous system, where 5-HT release patterns from the basolateral (i.e., bo

  2020-09-29

• Handheld endomicroscope using a fiber-optic harmonograph enables real-time and in vivo confocal imaging of living cell morphology and capillary perfusion

  AbstractConfocal laser endomicroscopy provides high potential for noninvasive and in vivo optical biopsy at the cellular level. Here, we report a fully packaged handheld confocal endomicroscopic syste

  2020-09-21

• Plasma-based early screening and monitoring of EGFR mutations in NSCLC patients by a 3-color digital PCR assay

  AbstractBackgroundNoninvasive plasma-based detection of EGFR mutations using digital PCR promises a fast, sensitive and reliable approach to predicting the efficiency of EGFR-TKI. However, t

  2020-08-20

• Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer – translational results from the AIO-PK0104 Phase 3 study

  AbstractBackgroundGram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated

  2020-08-10

• Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma

  AbstractBackgroundGastroesophageal adenocarcinoma (GOA) has poor clinical outcomes and lacks reliable blood markers. Here we present circulating tumour DNA (ctDNA) as an emerging biomarker.MethodsFort

  2020-07-28

• Engineering synthetic breath biomarkers for respiratory disease

  AbstractHuman breath contains many volatile metabolites. However, few breath tests are currently used in the clinic to monitor disease due to bottlenecks in biomarker identification. Here we engineere

  2020-07-20

• Temporary IVC Filter Reduces Neurosurgery Complications in Thrombophilic Patients

  Thrombophilic patients undergoing elective neurosurgery who receive a temporary inferior vena cava (IVC) filter show dramatically fewer thrombotic or hemorrhagic complications compared with thrombophi

  2020-06-28