• Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells

  AbstractChoroidal neovascularization induced by age-related macular degeneration and retinal neovascularization induced by diabetic retinopathy—two leading causes of blindness—are often treated using

  2021-07-02

• Landmark CRISPR trial shows promise against deadly disease

  The CRISPR–Cas9 complex (white and blue) can cut DNA (green), disabling genes that cause disease.Credit: Ella Maru Studio/Science Photo LibraryPreliminary results from a landmark clinical trial sugges

  2021-06-02

• COVID research: a year of scientific milestones

  Nature waded through the literature on the coronavirus — and summarized key papers as they appeared.

  2021-05-12

• Genetic therapies offer new hope against incurable brain diseases

  Update: Since this story was published, the Roche and Wave Life Sciences trials mentioned in the feature have been halted, owing to the drugs’ disappointing performance.Susan was still a child wh

  2021-04-01

• Phenotypic diversity and metabolic specialization of renal endothelial cells

  Complex multicellular life in mammals relies on functional cooperation of different organs for the survival of the whole organism. The kidneys play a critical part in this process through the maintena

  2021-03-20

• High-throughput screening and validation of antibodies against synaptic proteins to explore opioid signaling dynamics

  Antibodies represent powerful tools to examine signal transduction pathways. Here, we present a strategy integrating multiple state-of-the-art methods to produce, validate, and utilize antibodies. Foc

  2021-02-02

• Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

  Precision antimicrobials aim to kill pathogens without damaging commensal bacteria in the host, and thereby cure disease without antibiotic-associated dysbiosis. Here we report the de novo design of a

  2021-01-20

• Toll-like receptor signalling in B cells during systemic lupus erythematosus

  AbstractB lymphocytes have a central role in autoimmune diseases, which are often defined by specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease associated with

  2020-12-18