• Prognostic impact of peripheral blood neutrophil to lymphocyte ratio in advanced-stage pulmonary large cell neuroendocrine carcinoma and its association with the immune-related tumour microenvironment

  AbstractBackgroundThe prognostic value of the neutrophil-to-lymphocyte ratio (NLR) with large cell neuroendocrine carcinoma (LCNEC) patients remains unclear. Thus, we performed a retrospective study t

  2020-11-30

• Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

  AbstractIn December 2019, a novel coronavirus was isolated from the respiratory epithelium of patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute respiratory syndrom

  2020-10-19

• Antibody engineers seek optimal drug targeting TIGIT checkpoint

  Four antibodies are already in trials to test efficacy against the emerging checkpoint molecule TIGIT, but debate swirls around the importance of Fc binding for drug action.The race to develop a first

  2020-09-19

• The COVID-19 XPRIZE and the need for scalable, fast, and widespread testing

  To the Editor — The US Food and Drug Administration (FDA) Emergency Use Authorization (EUA) and Instructions for Use (IFU) documents outlining the current approved virology tests for SARS-CoV-2 a

  2020-08-20

• Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters

  AbstractWe developed a functional lineage tracing tool termed CaTCH (CRISPRa tracing of clones in heterogeneous cell populations). CaTCH combines precise clonal tracing of millions of cells with the a

  2020-07-28

• Concurrent use of palbociclib and radiation therapy: single-centre experience and review of the literature

  AbstractPalbociclib in combination with endocrine therapy increases progression-free survival in patients with ER-positive, HER2-negative advanced breast cancer (BC). In this study, we retrospectively

  2020-06-29

• Evaluation of the activity of a chemo-ablative, thermoresponsive hydrogel in a murine xenograft model of lung cancer

  AbstractBackgroundMinimally invasive intratumoural administration of thermoresponsive hydrogels, that transition from liquid to gel in response to temperature, has been proposed as a potential treatme

  2020-05-05

• Expression of RARRES1 and AGBL2 and progression of conventional renal cell carcinoma

  AbstractBackgroundApproximately 15% of clinically localised conventional renal cell carcinoma (RCC) will develop metastasis within 5 years of follow-up. The aim of this study was to identify biomarker

  2020-04-03